Ruth Ann Crystal, MD @CatchTheBaby
Ob/Gyn Dr, Innovator, Baker, Francophile. Love to learn. Stanford Clinical Faculty. Weekly COVID news: https://t.co/6IA2uPNsvv Bluesky: @drruth.bsky.social drruth.substack.com Silicon Valley, California Joined July 2009-
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Check out these talk summaries from our recent PolyBio Symposium👇 Highlights include that four groups — Tim Henrich (UCSF), Marcus Buggert (Karolinska), Nicolas Huot (Institut Pasteur), and Esen Sefik (Yale) — presented different lines of evidence (human gut biopsies, non-human primate models, humanized mice) all pointing to the same conclusion: SARS-CoV-2 persists in #LongCovid gut tissue and adjacent lymphoid structures, and that persistence drives ongoing immune dysregulation.
Written summaries of PolyBio’s Spring symposium presentations are available now! Check out shortened, simplified summaries, or full technical explanations of your favourite research projects. Interactive resource: …-spring-symposium-polybio.netlify.app #longcovidresearch #mecfsresearch
🚨FDA just approved XOCOVA (Ensitrelvir) pill for COVID post-exposure prophylaxis (PEP). 🔹First oral pill to PREVENT COVID after exposure 🔹67% risk reduction through Day 10 🔹Works regardless of vaccination status Game changer. buff.ly/XM0sLu8 #COVID #publichealth
📢"A cohort study of 457,950 hospitalized #COVID patients across 58 US hospitals using AI found that *1 in 6* patients (16.3%) had #LongCOVID, with 89% of those cases progressing to chronic conditions. MORE AT Dr. Ruth Report, 5/31/26, by @CatchTheBaby open.substack.com/pub/drruth/p/d…
A new animal study suggests that exposure to the SARS-CoV-2 Spike protein during early brain development may have lasting neurological consequences, even in the absence of active viral infection. ➡️ In neonatal mice, a single exposure increased seizure susceptibility, triggered brain inflammation, and caused loss of both excitatory and inhibitory synapses in key brain regions. 1/ H/T: @CatchTheBaby
@VstocksV So far, it is being tried on other autoimmune diseases. Some cases of Long COVID may have autoimmunity as a root cause, but this therapy needs to be tried on others first.
This week in Science 🧪 🔹 1 in 6 people has Long COVID; Billing codes miss >50% 🔹 Autoantibodies cause Long COVID neuro symptoms 🔹 Long COVID⬆️ CV risks & death 🔹 CAR therapy resets Autoimmune diseases 🔹 Hope for Pancreatic Cancer Dr. Ruth Report 👉 buff.ly/6eylV1s
Dr. Ruth Report, 5/31/26, by @CatchTheBaby open.substack.com/pub/drruth/p/d…
Experiments in human stem cell–derived neurons and hamster models showed that both live virus and the viral spike protein could induce this injury. ➡️ Importantly, blocking TRPV1 with the drug capsazepine reduced neuronal damage and preserved nerve integrity, suggesting that TRPV1-targeted therapies may help prevent or treat COVID-19–related anosmia. 2/2 H/T: @CatchTheBaby cell.com/iscience/fullt…
When a keyboardist fell ill mid-performance, composer Justin Hurwitz asked the 2,000-person audience for a sight reader. 21-year-old Sterling Nasa stepped up, delivered a solo on "Start a Fire," and walked away considering music as a career. buff.ly/GsvmZFF
This week in Science 🧪 🔹 1 in 6 people has Long COVID; Billing codes miss >50% 🔹 Autoantibodies cause Long COVID neuro symptoms 🔹 Long COVID⬆️ CV risks & death 🔹 CAR therapy resets Autoimmune diseases 🔹 Hope for Pancreatic Cancer Dr. Ruth Report 👉 buff.ly/6eylV1s
New JAMA Network Open study: 📊 Long COVID prevalence estimated at ~16% 🏥 58 U.S. hospitals 🤖 AI-based EHR phenotyping ⚠️ Diagnosis codes alone missed many cases The burden of #LongCOVID is likely much larger than initial data suggest. jamanetwork.com/journals/jaman…
Update from my colonoscopy yesterday: Procedure went smoothly! The prep wasn’t bad - pro tip: a clear liquid diet the day before (eg broth, apple juice, clear Jell-O) makes it much easier. And butt wipes (trust me). Found one polyp, which was removed. Awaiting biopsy results, but that’s exactly why we screen: early detection saves lives. DYK: Colonoscopies can⬇️ colorectal cancer risk by 69% and deaths bu 88% by catching and removing precancerous polyps early! If you’re 45+, talk to your doctor about screening. Don’t wait - peace of mind is worth it!
Several of these biological changes — especially markers linked to inflammation, low-oxygen stress, and mitochondrial function — were strongly associated with symptom severity. ➡️ The findings support the idea that LongCOVID is a complex “immunometabolic” condition involving coordinated disturbances in immune regulation, cellular energy production, and cell survival pathways, rather than a purely psychological or isolated post-viral syndrome. 2/2 H/T: @CatchTheBaby nature.com/articles/s4159…
Neurological consequences of Covid infections with Shingles leading to further downstream conditions, journal link in the post
COVID raises your shingles risk. New data from 110,000+ patients out of Taiwan shows that post-COVID Shingles also raise risk of ➡️ Bell's palsy ➡️ Guillain Barré ➡️ Myasthenia Gravis Worst of all? Neurological vulnerability lasts for at least 3 years. buff.ly/H1N73zd
Calling all #disabled folks in #medicine! Our board member Zoey is seeking participants for an anonymous online survey (15-30 min) for her dissertation/thesis! Share your experiences with community, mentorship, and more! uic.ca1.qualtrics.com/jfe/form/SV_cA… #DocsWithDisabilities
How do you navigate medicine with a #disability or #ChronicIllness? Take my Anonymous, 15-30 min thesis/dissertation survey! YOU are the expert in your experience--help produce knowledge about #DocsWithDisabilities! Link: uic.ca1.qualtrics.com/jfe1/form/SV_c… More info below.
Know anyone who participated in this trial?
La COVID augmente votre risque de zona. De nouvelles données provenant de plus de 110 000 patients de Taïwan montrent que le zona post-COVID augmente également le risque de ➡️ Paralysie de Bell ➡️ Guillain-Barré ➡️ Myasthénie grave Le pire de tout? La vulnérabilité neurologique dure au moins 3 ans.
COVID raises your shingles risk. New data from 110,000+ patients out of Taiwan shows that post-COVID Shingles also raise risk of ➡️ Bell's palsy ➡️ Guillain Barré ➡️ Myasthenia Gravis Worst of all? Neurological vulnerability lasts for at least 3 years. buff.ly/H1N73zd
Are ME/CFS and Long COVID the same? New immune profiling says NO. A new study of PBMCs reveals distinct pathophysiologies: ➡️ Long COVID shows chronic immune overactivation ➡️ ME/CFS shows immune suppression Crucial data for targeted treatments. buff.ly/6R6OCwd
COVID raises your shingles risk. New data from 110,000+ patients out of Taiwan shows that post-COVID Shingles also raise risk of ➡️ Bell's palsy ➡️ Guillain Barré ➡️ Myasthenia Gravis Worst of all? Neurological vulnerability lasts for at least 3 years. buff.ly/H1N73zd
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile)
Camille A. Clare MD M... @cclareMDMPH
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Christina Farr @chrissyfarr
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Jocelyn J. Fitzgerald... @jjfitzgeraldMD
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Gretchen Winter, MD �... @gretchemaben
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Tan Theory 💜 Scruf... @4Livingtheory
881 Followers 2K Following @4livingtheory at other social place b ; MSC Health Policy, Planning & Finance; Jill of many trades Teacher, Paralegal, admin at gov agencies, HR,
FTP/ACAB 🍉 @bluesparky666
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2K Followers 6K Following UVA Commerce '58, Law '61. Retired in Gaithersburg MD. Photography is a hobby. We enjoy travel, art, food and wine. Life is good!
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Nyfiken i en strut @MichHolmstrom
251 Followers 329 Following Långtidscovid (inkl. POTS) och andra viktiga samhällsfrågor. (Insjuknade mars -20.) Hoppas på forskningen.🙏🏼
Mrs.Sam Thesis @SThesis
11K Followers 11K Following USA Conservative. Married. I’m a grandma. No DM’s, please, unless I okay it. 1A. 2A. Direct descendent of original 1776 patriots.
Indy🔻#BLM @indy_yet
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Denis - The COVID inf... @BigBadDenis
18K Followers 3K Following Sharing info on COVID since the start of the pandemic
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Jocelyn J. Fitzgerald... @jjfitzgeraldMD
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Hannah Davis @ahandvanish
56K Followers 4K Following Research, algorithmic music, anti-bias in AI data. #LongCovid research & advocacy @patientled. DMs rarely checked
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42K Followers 852 Following Bridge builder & strategist. EVP, Chief Innovation & Commercialization Officer. In pursuit of person-centered value-based health & care. Tweets are my own.
Gretchen Winter, MD �... @gretchemaben
30K Followers 7K Following I believe in loving others. Animal rescuer. Life explorer. Bibliophile. Photographer. PCCM. Passions =🎼/💃/✈️/MedEd/Communication/Wellness. #BLM 🌈 She/Her
Alyssa Jaffee @AlyssaJoyJaffee
14K Followers 1K Following VC Partner @7wireventures empowering consumers to be better stewards of their health. Digital health enthusiast. Storyteller. Boy mom x 3!
Nick Adkins @nickisnpdx
31K Followers 545 Following kilt wearing pink furry bike riding healthcare MBA. 🌍💖😊 the world is full of good! when u believe it, u see it. keep doing that! ✨ #pinksocks
Putrino Lab @PutrinoLab
36K Followers 406 Following We make people (and technology) better at Mount Sinai. Opinions are my own.
Amy G Dala MD @AmyGDalaMD
34K Followers 1K Following fueled by coffee, fluent in sarcasm, lover of naps, always searching for where I parked my car
Chris Carroll MD @ChrisCarrollMD
20K Followers 3K Following #PedsICU Critical Care Doc. Deputy Editor @journal_CHEST. Father, educator, #zentensivist, @kate_moorehead’s husband.
Kelly “MIGS Lady”... @MigsRunner
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RemissionBiome MECFS/... @remissionbiome
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FLAVOR FLAV @FlavorFlav
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Jess @MeetJess
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14K Followers 192 Following Severe #LongCovid since Nov '22. Previously: running, iOS, photography.
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Jake Scott, MD @jakescottMD
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702 Followers 22 Following
Sen. Bernie Sanders @SenSanders
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Fe. @NoHealthNoFun
3K Followers 898 Following Canary in the coal mine 🐤 rotting with #LongCovid since May 22. Looking for scientific insights and community. #Prevention is the way forward. 😷 Wear a respie
Barbara @egervasics2
468 Followers 744 Following Carer for daughter with severe MECFS caused by SARS-Cov2 #StandWithUkraine #ArmUkraineNow #Klimaschutz 🇪🇺 🌈#Longcovid #MECFS #MCAS
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43K Followers 2K Following I buy and sell antiques. I sow and grow flowers. Instagram an_acre_of_flowers UK 🇬🇧 THIS IS MY ONLY ACCOUNT
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