Nicola Pozzi @LabPozzi

Novel insights into #APS extend beyond #Thrombosis to NETosis, #ComplementActivation and #MicrobiomeDysbiosis. The 2023 ACR/EULAR criteria refine diagnosis. Adjunctive therapies such as HCQ, rituximab and eculizumab show therapeutic potential: pmc.ncbi.nlm.nih.gov/articles/PMC12… #MedTwitter

🏅Celebrating 50 Years of Service: Honoring Dr. Terry Moore’s Legacy in #Rheumatology | @SSMHealthSTL #InternalMedicine 🩺🏥 🫶🏼The IM Department is privileged to celebrate Dr. Moore’s remarkable 50 years of dedication and leadership in building the legacy of our Rheumatology division. Over the past five decades, Dr. Moore has: 🔹 Pioneered approaches that have shaped how #autoimmune diseases are diagnosed and managed. 🔹 Mentored countless trainees, faculty, and colleagues who continue to carry his impact forward. 🔹 Contributed groundbreaking insights into the role of laboratory studies + the art of clinical diagnosis in guiding patient care. Beyond his scientific and clinical achievements, Dr. Moore’s commitment to #Mentorship, #collaboration, & #innovation has left a lasting mark on our institution and the broader medical community. 🌟 🙏🏽 @RaviNayakMD➕Sally Day➕others for organizing a special event including Dr. Moore's #GrandRounds lecture on ‘Autoimmunity and Laboratory Studies in Connective Tissue Disease’, tributes & networking 🤝🏽 August 22, 2025 🫶🏼 Dr. Raymond Slavin for heartfelt tribute to Dr. Moore 🎤 Please join us in celebrating Dr. Moore's extraordinary career & enduring contributions to research, education, and patient care. 👏🏽 #SLUProud #SLUResearch #Rheumatology #ConnectiveTissueDisease #MedicalEducation #Mentorship #CelebratingExcellence | @SLU_Official | @slusom | @SSMHealth | @nephrom | @renginels | @Barisafsar75 | @GkamelMD | @sagun_goyal | @linamariat50445 🩺🏥

New insights to consider in the clinical approach to #TMA: rpthjournal.org/article/S2475-… On the lack of response to #complement blockade therapy and high rates of recurrence among patients with #plasminogen variants. #anticoagulation #cmTMA @anuja_java

GRASP: a model for protein complex structure prediction that integrates data from crosslinking, covalent labeling, chemical shift perturbation, and deep mutational scanning experiments. @PKU_CCME @Turnstiles14 nature.com/articles/s4159…

Congratulations to 2025 APSACTION Silvia Pierangeli Young Scholar Award (in collaboration with APS Foundation of America) Recipients: Alice Barinotti, Zeynep Erton, Alex Luta, Liala Moschetti, Andrew Song. During #ICAPA25, Alice and Zeynep received their certificates in person.

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Is someone you love at risk for an aortic aneurysm? This Aortic Disease Awareness Month, take a moment to learn the risk factors, understand who should be screened, and find out how testing can help save lives: bidmc.org/aorticscreening

Did you know that #Plasminogen activation and plasmin activity are not necessary to #prevent venous thrombosis/thromboembolism ashpublications.org/blood/article/…

Latest publication in @jlipidres “The Risk of Going Outside: Amino Phospholipids in Rheumatoid Arthritis” by @LabPozzi et al. jlr.org/article/S0022-… @ASBMB

🧬 New in @RPTHjournal. Led by @ShreyaAgarwalMD 
We share a case series of #TMA pts with Plasminogen mutations ✅Variable response to complement blockade ✅Structural mapping by @LabPozzi provides insights into potential mechanisms!! rpthjournal.org/article/S2475-…

The 3-decade-old competition that enabled the emergence and evaluate of AlphaFold has run out of NIH funding. The program will be terminated in weeks. This is terminating success. science.org/content/articl…

ASH is proud to recognize 11 hematologists whose groundbreaking research and leadership have transformed the understanding and care of blood disorders. Congratulations to all! 👏 🔗 ow.ly/EsgX50WbEwx #Hematology #ASHAwards

Patients with cancer are at high risk of clinically relevant bleeding, regardless of anticoagulation use. ow.ly/upqz50UgFrV #thrombosisandhemostasis #clinicaltrialsandobservations

I have had the honor of serving on the @HTRStoday 2025 Scientific Symposium planning committee over the last year. There is going to be a great program. We have a record number of abstracts submitted. Make plans now to attend in March 2025!!

Life is a melody, with enzymes as instruments and ligands as music directors. We show how two ligands binding to the same pocket of an enzyme can produce different melodies—the magic of allostery! Great job, Ponzar, Chinnaraj et al. @SLUbiochem, @HemeThrombBIDMC, and @UniPadova

JTH @JTHjournal

2 years ago

Protein Disulfide Isomerase (PDI) is an exciting new target for the treatment of thrombosis. This study uncovers the mechanistic basis by which two promising compounds, quercetin-3-O-rutinoside and bepristat-2a, regulate PDI. An important step toward the development of

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Protein Disulfide Isomerase (PDI) is an exciting new target for the treatment of thrombosis. This study uncovers the mechanistic basis by which two promising compounds, quercetin-3-O-rutinoside and bepristat-2a, regulate PDI. An important step toward the development of PDI-targeting drug. ✍️@LabPozzi jthjournal.org/article/S1538-…

Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

T-48 hrs until the start of our 3rd Annual @WashUHeme Retreat! Excited to hear about the latest research from our trainees & faculty, and especially thrilled to welcome @aswolberg for the Evan Sadler Special Lectureship! #hematology @WashUDeptMed

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🧐...By demonstrating distinct functional profiles of Type-I and Type-II anti-prothrombin autoantibodies in human plasma, we introduce a new concept: the Antiphospholipid Syndrome Autoantibody Atlas (APSAA)...💡🤯... Check it out... doi.org/10.1016/j.jtha…

Does inflammation interfere with lupus anticoagulant testing in the Russel Vioer venom assay? 🐍 Read this article from Michael Hardy and team to find out : rpthjournal.org/article/S2475-…

📢Publication News! Congratulations to @abigailrballard @roberthlee @BergmeierLab for their publication in @BloodJournal. @UNC_BCBP @UNCBBSP ashpublications.org/blood/article-…