Taufiq Rahman @RahmanLab
small molecules enthusiast; loves ion channels & Fender Stratocaster; a dabbler in drawing; views my own https://t.co/za3Gxnq5xd phar.cam.ac.uk/research/rahman Joined October 2015-
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Come and join us @UnivCamPharm for a PhD with @MaxionTx findaphd.com/phds/project/r… Deadline: July 30th Funding: Home Fee status only
Want to help shape the future of Cambridge? 🧐 Join students from across the University for the Cambridge Student Summit – a day of interactive discussions, workshops, and student-led conversations with local leaders and community organisations. 📅 Thursday 18 June, 9.30am–4pm 📍 Cambridge Guildhall 🎫 Free to attend (limited spaces available) 🍴 Lunch and refreshments provided Book your place now 👉 bit.ly/4dPUnAA
Indigenous Peoples are at the 💚 of protecting some of the most vital ecosystems on Earth. They live on and manage roughly 22% of the world’s land, territories that overlap with many of the planet’s most biodiverse and ecologically intact areas. go.undp.org/qs5
We may speak thousands of languages, but we all call this planet home. No matter where we come from, protecting our Earth is a shared responsibility. We need more ambitious #ClimateAction — for our planet and the generations to come. — via @UNDP
A unified ensemble-allosteric framework reconciles gain- and loss-of-function disease mutations in the IP3 receptor 1. The study proposes a single ensemble-allosteric model to explain why nearby missense mutations in IP3R1 can cause opposite phenotypes (gain-of-function vs loss-of-function) while the N-terminal fold remains largely intact. 2. By combining in silico saturation mutagenesis with ProteinMPNN/ThermoMPNN and AlphaMissense, pathogenic substitutions are shown to cluster in a “stability-preserving but locally incompatible” regime: mutations tend to disrupt local sequence–structure compatibility without strongly destabilizing the global N-terminal architecture. 3. This reframes IP3R1 channelopathy: disease is driven less by unfolding or structural collapse, and more by corruption of conformational probabilities and allosteric information flow linking ligand recognition to gating. 4. Using BioEmu to sample 1,000 conformations per variant (filtered to retain native-like SD–IBC architecture), the IP3-binding pocket is shown to occupy a discrete multi-basin conformational landscape. Clustering in a pocket-local UMAP embedding identifies three reproducible pocket substates (A–C). 5. Loss-of-function variants tend to reweight these pre-existing pocket substates rather than creating entirely new structures. The LOF mutation R269W shows the strongest redistribution, markedly enriching a rare pocket substate and depleting the WT-dominant one. 6. Pocket physicochemistry explains the R269W LOF mechanism: replacing a cationic IP3-coordinating Arg with bulky Trp reduces pocket volume, lowers positive/charge character, and increases hydrophobicity—changes that are unfavorable for binding a highly phosphorylated ligand like IP3. 7. Adaptive MD (2 μs aggregate per system) plus Markov state models reveal that WT pocket dynamics form a connected three-state kinetic network with efficient exchange. R269W preserves three metastable states but reroutes transitions: exchange from a minor to dominant basin becomes predominantly intermediate-mediated, reducing direct kinetic connectivity between key pocket basins. 8. In contrast, the GOF suppressor-domain mutation R36C keeps a broadly WT-like pocket ensemble and more WT-like pocket kinetics, arguing that GOF does not require local pocket “activation” or collapse. Instead, its effect is distal and allosteric. 9. Contact-informed dynamical network analysis links R36C GOF to weakened suppressor-domain restraint: SD-to-pocket communication is redistributed onto longer, less efficient pathways (increased weighted shortest-path cost), with rewiring of residues/edges near pocket-adjacent loops and altered community organization—consistent with allosteric decoupling rather than pocket failure. 📜Paper: biorxiv.org/content/10.648… #ComputationalBiology #MolecularDynamics #Allostery #ProteinEnsembles #MarkovStateModels #CalciumSignaling #Neurogenetics #IP3R #ITPR1 #VariantInterpretation
Wishing a happy Eid al-Adha to all our students, staff, alumni and friends celebrating in Cambridge and around the world 🌙
Today we wish Bob Dylan a happy 85th birthday. Listen to this excerpt from Dylan's Nobel Prize lecture where he reflects on the literary influences that shaped his songwriting. Classic works like 'Moby-Dick', 'All Quiet on the Western Front', and 'The Odyssey' informed his understanding of storytelling and human nature. Hear the full lecture: bit.ly/4kI1Qm5
very pleased to see this online near-final version. Really enjoyed collaborating with the Moreno group on this exciting project and glad that I could contribute nature.com/articles/s4146…
Thinking about postgraduate study at Cambridge as an international student? 🤔 Our international postgraduate funding webinar series is a deep dive into our scholarships and awards available to international students, including opportunities from Cambridge Trust, Gates Cambridge, and regional partners. Don't miss the opportunity to understand your funding options and join the session in your time zone! ⏰ Register today through the link 👉 bit.ly/4eNxrTz #CambridgeUniversity #Cambridge #Postgraduate
Metformin, one of the most commonly prescribed drugs, was thought to work via the liver. Check that. It's primarily through the gut. @NatMetabolism nature.com/articles/s4225…
'Interstitial cells of Cajal – pacemakers of the #gastrointestinal tract' Kenton M. Sanders (@unrmed), L. Fernando Santana (@ucd_physiology) & Salah A. Baker summarise key mechanisms responsible for electrical rhythmicity in gastrointestinal organs⚡️🔎 buff.ly/jU2NDzs
if you are interested in ion channels, calcium signalling or computational biophysics and eligible for the fellowship application, feel free to be in touch: snf.ch/en/XIZpfY3iVS5…
very pleased to play some part in this exciting study led by Clémence and colleagues sciencedirect.com/science/articl…
🔬Fully funded PhD Applications are open for the BBSRC–GSK Transformative Technologies in Pharmaceutical Science programme! Apply by 15 May 2026 👉postgradschl.lifesci.cam.ac.uk/funding/transf… #PharmaceuticalScience #CambridgeUniversity #GSK
@psalmotoxin the glance is giving clear message here - 'don't disturb me - I ain't moving out of here'
Are you 19 or over and now thinking about university for the first time? 💭 Cambridge 21+ is a hybrid residential programme, run by @Hughes_Hall, @WolfsonCam and @StEdmundsCam, for mature students who have never been to university before 🏫 Sign up now 👇 bit.ly/4bWU0U2
Dept. of Pharmacology... @UnivCamPharm
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Ewan St. John Smith @psalmotoxin
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accardilab @accardilab
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ddddd @rowdata27
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Shi-Bing Yang @SBY00620144
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Sama Alhalalmeh @jordan59037691
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David Ascher @DrDavidAscher
581 Followers 474 Following Deputy Associate Dean of Research, Director of Biotechnology Programs @UQ_News & @BakerResearchAu | Using the power of AI in biotech and beyond
(Parody) Cambridge Bi... @BiocCamTruth
158 Followers 3K Following Commentary & critique through a truthful lens on the dysfunction, corruption & failed leadership we couldn’t fix from within. Not affiliated with Cambridge Uni.
Desiree Mante @DesireeMan34621
83 Followers 3K Following
Shijie He @HeshijieHe
136 Followers 4K Following First-class undergraduate of Westlake University @Westlake_Uni, 2024 Fall exchange @UCSD, PhD Candidate @UTSWMedCenter, keen in neurodegeneration therapies
Yui Ngan @guyngan1
186 Followers 516 Following Postdoc @UnivCamPharm working with @psalmotoxin and naked mole-rat. Evolution, genomics, tRNA, biofilms, metagenomics, etc. Also on https://t.co/WbaVDPWSLX
jianming @DrJianming_Han
25 Followers 223 Following
Dept. of Pharmacology... @UnivCamPharm
2K Followers 335 Following Dept. of Pharmacology @Cambridge_Uni within @Cambridge_SBS
Ewan St. John Smith @psalmotoxin
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Ardem Patapoutian @ardemp
51K Followers 263 Following @scrippsresearch Professor. @HHMINEWS Investigator. @NobelPrize 2021. Research: touch & other forms of pressure sensing. Find me at @ardemp.bskyverified.social
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Journal of General Ph... @JGenPhysiol
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902 Followers 187 Following Manxman Scientist. Neurobiologist, Group Leader, Interests: ion channels, extreme biology, mole-rats, sensory transduction, touch, pain, social brain, flying
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77K Followers 85 Following The original Cambridge Diary. 5,000 continuous daily pictures of Cambridge curated into a trilogy of photographic love letters https://t.co/l30mAx0Yd6
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Science Magazine @ScienceMagazine
4.7M Followers 458 Following Cutting-edge research, news, commentary, and visuals from the Science family of journals. Follow @NewsfromScience for stories from our News team.
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601 Followers 400 Following Professor of Pharmacology at Pitt. Investigator at the Vascular Medicine Institute. Interested in calcium signaling in physiology and disease.
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Google for Education @GoogleForEdu
756K Followers 787 Following For the art of teaching 🎨 and the science of learning 🧪. Follow #GoogleEdu for the latest in #AI, #Chromebooks, product updates, resources, & more!
Google Gemini @GeminiApp
515K Followers 50 Following The Gemini app turns research into reality, bringing frontier AI experiences like Omni, Deep Think, Nano Banana, and more to hundreds of millions of people.
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5K Followers 203 Following Mission: design of biological interventions for environment and human health (to save the world)
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449 Followers 166 Following Nick is interested in the neurophysiological basis of pain pathways in visceral organs, and the neural control mechanisms of the enteric nervous system.
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540 Followers 450 Following Assistant Professor studying core principles of lysosomal biology in aging and age-related disease @AgingPitt @PittTweet
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553 Followers 225 Following Ion channels, transporters, glia, glia-neuron crosstalk. Director of the Cellular Physiology and Molecular Biophysics graduate program, University of Miami.
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Marinka Zitnik @marinkazitnik
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Michael R Tadross @miketadross
624 Followers 680 Following Dad | Engineer | Neuroscientist | BLM | Lift As You Climb
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407 Followers 287 Following PhD student at @uwcse + @UWproteindesign working on machine learning for protein design, protein language models, etc.
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12 Followers 194 Following
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327 Followers 627 Following Prof at unito and visiting in lille. Science interest in cell Physiology #ionchannels #trpchannels #calciumsignaling #francophonie
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7.8M Followers 2K Following A husband, father, actor, director, & a climate justice advocate with an eye out for a better, brighter, cleaner, & more hopeful future for all of us.
Ricardo Serafim @ramserafim
229 Followers 541 Following Assistant Professor of Medicinal Chemistry at IQS, School of Engineering, Barcelona 🇪🇸🇧🇷
Ekene Anakor @EkeneA28
399 Followers 923 Following Interested in neurodegenerative diseases, disease modelling, drug discovery & development. Assistant Professor in Pharmacology @UoB_Pharmacy. RT ≠ Endorsement
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189K Followers 2K Following I would rather die of passion than of boredom - V. van Gogh.
Matt Dancho (Business... @mdancho84
100K Followers 514 Following Generative AI, Data Science, Python, and Business (ROI). Join my next live AI workshop (free).👇
ALLODD @ALLODD_ITN
302 Followers 222 Following Allostery in Drug Discovery ITN Marie Skłodowska-Curie network. ALLODD receives funding from the @EU_H2020 Research & Innovation Programme under GA No. 956314.
The Night Science Pod... @nightsciencepod
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UC Davis Physiology @ucd_physiology
870 Followers 448 Following Founded in 1966, the Department of Physiology and Membrane Biology is one of five basic science departments in the @UCDavisMed.
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