Pavle Jeremić @SynBioMars

This time, I am publishing in full the album authored by TsKBEM in 1969, dedicated to the mock-up article N1-L3 №1M1, built for the comprehensive development of the rocket-space system. 1/16

42 354 3K 330K 1K

0 0 0 161 0

View Details

Multiplexing can be thought of as "GPU-ification" of a complex biological system Serial measurement becomes massively parallel To turn biology digital, you need data at *scale* and *relevance* The power of multiplexing is you get both.

Seth Bannon @sethbannon

2 months ago

Multiplexed in vivo screening is the future of drug development. @ManifoldBio is multiplexing protein therapies in vivo. @GordianBio is multiplexing gene therapies in vivo. @waypointbio is multiplexing cell therapies in vivo. GT Bio is multiplexing LNPs in vivo. 50Y portcos all

7 19 186 37K 166

4 18 91 72K 55

View Details

Circe @vocalcry

2 months ago

My HOA is two weeks away from developing a nuclear weapon

548 7K 109K 1.6M 2K

View Details

Pavle Jeremić @SynBioMars

2 months ago

Co-design is the future! Any effort to design de-novo functions must include both the protein design and the actual molecular function/target in model, awesome work here further validating that strategy

Jarrid Rector-Brooks @jarridrb

2 months ago

What if AI could invent enzymes that nature hasn’t seen? 👩‍🔬🧑‍🔬 Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design 14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the

32 244 1K 276K 789

0 0 2 137 0

View Details

Kane 謝凱堯 @kane

2 months ago

San Francisco has failed at infrastructure for so long that reporters will look at a 25 story building and call it "inconceivable" and "sci-fi"

Mission Local @MLNow

2 months ago

Even the sci-fi film "Big Hero 6" could not envision a San Francisco with tall buildings in the Marina. In the real world, one is likely coming to the Marina Safeway site. No matter what politicians or people calling for a boycott want. From @esksf missionlocal.org/2026/04/marina…

28 4 62 47K 10

16 49 867 29K 19

View Details

Pavle Jeremić @SynBioMars

2 months ago

Protein function models are the future! Requires massive multi-functional datasets to generalize not just to “natural” functions but also to push well beyond what nature evolved.

Prof. Nikolai Slavov @slavov_n

2 months ago

Progress in AI modeling of proteins leaves major gaps affecting most proteins and especially functional analysis. The opportunities to transcend them beacon: AI models can now predict static protein structures with high accuracy. This achievement is rightly celebrated. It is

8 38 172 55K 124

0 0 1 97 0

View Details

Christian Keil @pronounced_kyle

2 months ago

We need to make this true again.

23 13 419 17K 10

View Details

Daniel @growing_daniel

3 months ago

Make San Francisco a shitty place to be a drug addict

54 52 2K 55K 11

View Details

Noah Smith 🐇🇺🇸🇺🇦🇹🇼 @Noahpinion

3 months ago

Star Wars depicts a future where cybersecurity just doesn't work. They have AGI but they keep it bottled up in droids; they don't network anything. As soon as R2-D2 gets access to an actual network he successfully hacks the Death Star.

153 277 9K 290K 498

View Details

Pavle Jeremić @SynBioMars

3 months ago

One of the best sci fi series ever

Space Koala @SpaceKoala

3 months ago

People keep saying FAM is turning into to The Expanse, but it's actually going to become the Red Mars trilogy. And a space elevator on Mars was actually a major plot point for a Mars rebellion in that series.

30 54 754 36K 193

0 0 1 90 0

View Details

Crémieux @cremieuxrecueil

3 months ago

I've said it once, I'll say it again and keep repeating myself: No expensive housing market builds lots of housing. That is not a coincidence: build homes and prices are controlled!

Owen Zidar @omzidar

3 months ago

Striking graph from @esoltas and Jon Gruber

27 152 732 249K 208

32 112 1K 64K 211

View Details

Gianmatteo Costanza @emissionite

4 months ago

Whenever the Big One hits San Francisco and levels vast swaths of the city, we will finally confront an uncomfortable truth: we have outlawed our own existence. Cities built over generations cannot be rebuilt because our codes are anti-city, and most people don’t know it.

Sukrit Ganesh 🇺🇸 🥑 🚲🛩️ @SukritGanesh

4 months ago

Lahaina burned down in 2023. As of 2026, few homes have been rebuilt. One big reason why? Lahaina's zoning is one of the most restrictive in the US. Only low-density SFHs allowed. Most can hardly afford to rebuild. There is demand for new apartments, but the law prohibits it.

20 25 405 118K 26

37 110 2K 89K 117

View Details

Pavle Jeremić @SynBioMars

4 months ago

Sometimes biology come up with annoying terminology (see kinases) but other times it’s simply delightful

whimsy lohan (in NYC) @SexyLikeMeiosis

4 months ago

TIL about the existence of blebbisomes (large extracellular vesicles that contain everything but a nucleus) and they are named this because they, in the technical parlance, "bleb around" it's so WHIMSICAL i'm so happy bleb bleb bleb

14 196 2K 34K 226

0 0 4 92 0

View Details

Sam D'Amico @sdamico

4 months ago

This curve not being discontinuous with GPT-3 is fascinating

Callum Williams @econcallum

4 months ago

Datacentres now account for 7% of US electricity demand

104 605 3K 749K 507

31 25 2K 185K 221

View Details

Pavle Jeremić @SynBioMars

4 months ago

This is why all these startups have generally failed, algorithmic approaches for over 10 years have been able to find targets, but the real value unlock only happens well into clinical trials when safety and efficacy are determined!

Crémieux @cremieuxrecueil

4 months ago

Yep! We have so many drug targets. Finding targets is not the issue. The issue is testing them and going through the rigamarole to get them produced and on the market. AI-in-medicine people are missing this and talking about an area that just isn't the bottleneck to new drugs.

8 9 96 24K 30

0 1 2 349 0

View Details

Pavle Jeremić @SynBioMars

4 months ago

@chaitjo No

0 0 0 7 0

View Details

Pavle Jeremić @SynBioMars

5 months ago

@Patrick_Maksoud @p_maverick_b Yeah, generated internally is the only way, but I’ve at least not seen anyone outside of Aether generating the right type (and volume) of data to train these models